Puur Culico provides additional support to your horse suffering from eczema around the tail and manes. Puur Culico helps the body build a resistance against mosquito bites, reducing the severity of the reaction. Puur Culico should be administered immediately if you notice the horse starting to rub. Normally, the drops have to be applied for two consecutive years, from the months of March/April to October/November. During this time it becomes possible for the horse to build up resistance against mosquito bites. In some cases, this resistance becomes strong enough to be able to stop giving the drops after two years.